Details of the Drug Formulations

General Information of Drug (ID: DMI6E0R)

• Drug Name: Midostaurin Drug Info
• Synonyms: PKC412; 120685-11-2; Cgp 41251; 4'-N-Benzoylstaurosporine; CGP-41251; Benzoylstaurosporine; PKC-412; RYDAPT; PKC 412; UNII-ID912S5VON; N-Benzoylstaurosporine; ID912S5VON; CHEMBL608533; CHEBI:63452; Cgp 41 251; N-[(5S,6R,7R,9R)-6-methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-7-yl]-N-methylbenzamide; PKC-412(Midostaurin); Midostaurin (PKC412); Midostaurin (USAN/INN); Midostaurin [USAN:INN]; CGP 41231; Rydapt (TN); CPG 41251

Indication

Disease Entry	ICD 11	Status	REF
Acute myeloid leukaemia	2A60	Approved	[1]
Systemic mastocytosis	2A21.0	Approved	[2]
Chronic myelomonocytic leukaemia	2A40	Phase 2	[3]
Colorectal cancer	2B91.Z	Phase 1	[3]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 9829523
  ChEBI ID: CHEBI:63452
  CAS Number: 120685-11-2
  TTD ID: D07NVU
  VARIDT ID: DR01370
  INTEDE ID: DR1090
  ACDINA ID: D00431

Full List of Drug Formulations Containing This Drug

Midostaurin 25 mg capsule

Company	Formulation ID	FDA Description
Novartis Pharmaceuticals Corporation	F14055	Carminic acid; Alpha.-tocopherol; Ferric oxide red; Ferric oxide yellow; Glycerin; Propylene glycol; Titanium dioxide; Water; Polyethylene glycol 400; Polyoxyl 40 hydrogenated castor oil; Alcohol; Corn oil; Gelatin, unspecified; Hypromellose 2910 (10000 mpa.s)

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2018
• [2] 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5702).