General Information of Drug (ID: DMN3GCH)

Drug Name
Darunavir Drug Info
Synonyms
206361-99-1; TMC114; Prezista; TMC-114; UIC-94017; Darunavirum; TMC 114; Darunavirum [INN-Latin]; UNII-YO603Y8113; AIDS073035; CHEMBL1323; (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE; CHEBI:367163; Darunavir-d9; YO603Y8113; (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate; NCGC00168773-01; (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl; Darunavirum; Darunavir [USAN]; UIC 94017; Prezista(TM); UIC-96017; Darunavir (USAN/INN); Carbamic acid, [(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester; {(1S,2R)-3-[(4-Amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-carbamic acid (3R,3aS,6aR)-(hexahydro-furo[2,3-b]furan-3-yl) ester; [(S)-3-[(4-Amino-benzenesulfonyl)-isobutyl-amino]-2-hydroxy-1-((R)-phenylmethyl)-propyl]-carbamic acid (3R,3aS,6aR)-(hexahydro-furo[2,3-b]furan-3-yl) ester; N-((1S,2R)-3-(((4-Aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-benzylpropyl)((1S,2R,5R)-4,6-dioxabicyclo(330)oct-2-yloxy)carboxamide; [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate; (3-((4-aminobenzenesulfonyl)isobutylamino)-1-benzyl-2-hydroxypropyl)carbamic acid hexahydrofuro(2,3-b)furan-3-yl ester; (3R,3aS,6aR)-Hexahydrofuro(2,3-b)furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N1-isobutylsulfanilamido)propyl)carbamate; (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N(1)-isobutylsulfanilamido)propyl)carbamate; (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate; (3R,3aS,6aR)-tetrahydro-2H-furo[2,3-b]furan-3-yl (2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate; (3R,3aS,6aR)-tetrahydro-2H-furo[2,3-b]furan-3-yl (2S,3R)-4-(4-amino-N-neopentylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate
Indication
Disease Entry ICD 11 Status REF
Human immunodeficiency virus infection 1C62 Approved [1]
Human immunodeficiency virus-1 infection 1C62 Phase 3 [2]
Therapeutic Class
Antiviral Agents
Cross-matching ID
PubChem CID
213039
ChEBI ID
CHEBI:367163
CAS Number
206361-99-1
TTD ID
D03IGH
VARIDT ID
DR00514
INTEDE ID
DR0420
ACDINA ID
D00170

Full List of Drug Formulations Containing This Drug

Darunavir 400 mg tablet
Company Formulation ID FDA Description
State of Florida DOH Central Pharmacy F05264 Fd&c yellow no. 6; Magnesium stearate; Talc; Titanium dioxide; Crospovidone; Polyethylene glycol 3350; Polyvinyl alcohol; Silicon dioxide; Cellulose, microcrystalline
RemedyRepack F05265 Fd&c yellow no. 6; Magnesium stearate; Talc; Titanium dioxide; Crospovidone; Polyethylene glycol 3350; Polyvinyl alcohol; Silicon dioxide; Cellulose, microcrystalline
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Darunavir 600 mg tablet
Company Formulation ID FDA Description
State of Florida DOH Central Pharmacy F05266 Fd&c yellow no. 6; Magnesium stearate; Talc; Titanium dioxide; Crospovidone; Polyethylene glycol 3350; Polyvinyl alcohol; Silicon dioxide; Cellulose, microcrystalline
RemedyRepack F05267 Fd&c yellow no. 6; Magnesium stearate; Talc; Titanium dioxide; Polyethylene glycol 3350; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Microcrystalline cellulose; Polyvinyl alcohol, unspecified
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Darunavir 800 mg tablet
Company Formulation ID FDA Description
RemedyRepack F05269 Magnesium stearate; Ferric oxide red; Talc; Titanium dioxide; Polyethylene glycol 3350; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Hypromellose, unspecified; Microcrystalline cellulose; Polyvinyl alcohol, unspecified
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Darunavir 150 mg tablet
Company Formulation ID FDA Description
Janssen Products F05263 Magnesium stearate; Talc; Titanium dioxide; Polyethylene glycol 3350; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Microcrystalline cellulose; Polyvinyl alcohol, unspecified
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Darunavir 75 mg tablet
Company Formulation ID FDA Description
Janssen Products F05268 Magnesium stearate; Talc; Titanium dioxide; Polyethylene glycol 3350; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Microcrystalline cellulose; Polyvinyl alcohol, unspecified
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References

1 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)