Details of the Drug Formulations

General Information of Drug (ID: DMOQVU9)

• Drug Name: Hydroxyurea Drug Info
• Synonyms: Biosupressin; Droxia; Hidrix; Hidroxicarbamida; Hydrea; Hydreia; Hydroxicarbamidum; Hydroxyaminomethanamide; Hydroxycarbamid; Hydroxycarbamide; Hydroxycarbamidum; Hydroxycarbamine; Hydroxyharnstoff; Hydroxylurea; Hydura; Hydurea; Idrossicarbamide; Litaler; Litalir; Mylocel; NHY; Oncocarbide; Oxyurea; Siklos; Carbamide oxide; Carbamohydroxamic acid; Carbamohydroximic acid; Carbamohydroxyamic acid; Carbamoyl oxime; Carbamyl hydroxamate; Carrbamoyl Oxime; Hydroxyharnstoff [German]; Idrossicarbamide [DCIT]; H 8627; SK 22591; SQ 1089; DRG-0253; Droxia (TM); Droxia (TN); HYDREA (TN); HYDROXY-UREA; Hidroxicarbamida [INN-Spanish]; Hydrea (TM); Hydroxycarbamidum [INN-Latin]; Hydroxyurea (D4); Hydroxyurea (USP); Hydroxyurea [USAN:BAN]; Hydroxyurea(d4); N-Carbamoylhydroxylamine; N-HYDROXY UREA; N-Hydroxymocovina; N-Hydroxymocovina [Czech]; N-Hydroxyurea; Onco-carbide; SQ-1089; Tetratogen: inhibits ribonucleoside diphosphate reductase; Hydroxycarbamide (JAN/INN); N-(Aminocarbonyl) Hydroxyamine; Hydrea, Biosupressin, Cytodrox, Hydroxyurea; S-phase/G-1 interface inhibitor; 1-HYDROXYUREA

Indication

Disease Entry	ICD 11	Status	REF
Chronic myelogenous leukaemia	2A20.0	Approved	[1]
Desmoid tumour	2F7C	Approved	[2]
Fibromatosis		Approved	[2]
Head and neck cancer	2D42	Approved	[2]
Melanoma	2C30	Approved	[2]
Pulmonary hypertension	BB01	Approved	[2]
Sickle-cell anaemia	3A51	Approved	[2]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 3657
  ChEBI ID: CHEBI:44423
  CAS Number: 127-07-1
  TTD ID: D07CWD
  VARIDT ID: DR01177
  ACDINA ID: D00317

Full List of Drug Formulations Containing This Drug

Hydroxyurea 500 mg capsule

Company	Formulation ID	FDA Description
AvKARE; Physicians Total Care	F09899	Anhydrous citric acid; Methylparaben; D&c red no. 28; Lactose monohydrate; Propylparaben sodium; Sodium lauryl sulfate; Butylparaben; D&c yellow no. 10; Fd&c red no. 40; Benzyl alcohol; Fd&c blue no. 1; Fd&c blue no. 2; Magnesium stearate; Sodium propionate; Edetate calcium disodium; Ferric oxide red; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Carboxymethylcellulose sodium; Aluminum oxide; Gelatin; Shellac; Sodium phosphate, dibasic
Teva Pharmaceuticals	F09900	Anhydrous citric acid; Methylparaben; D&c red no. 28; Lactose monohydrate; Propylparaben sodium; Sodium lauryl sulfate; Butylparaben; D&c yellow no. 10; Fd&c red no. 40; Benzyl alcohol; Fd&c blue no. 1; Fd&c blue no. 2; Magnesium stearate; Sodium propionate; Edetate calcium disodium; Ferric oxide red; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Carboxymethylcellulose sodium, unspecified form; Gelatin; Shellac; Sodium phosphate, dibasic
E.R. Squibb & Sons	F09903	D&c red no. 28; Lactose, unspecified form; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Magnesium stearate; Citric acid monohydrate; Titanium dioxide; Gelatin; Sodium phosphate
American Health Packaging; Cardinal Health; Golden State Medical Supply	F09901	D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Magnesium stearate; Titanium dioxide; Silicon dioxide; Gelatin
Par Pharmaceutical; RemedyRepack	F09902	D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Magnesium stearate; Titanium dioxide; Silicon dioxide; Gelatin, unspecified

Hydroxyurea 300 mg capsule

Company	Formulation ID	FDA Description
E.R. Squibb & Sons	F09897	D&c red no. 28; Lactose, unspecified form; D&c red no. 33; Fd&c blue no. 1; Magnesium stearate; Citric acid monohydrate; Titanium dioxide; Gelatin; Sodium phosphate

Hydroxyurea 400 mg capsule

Company	Formulation ID	FDA Description
E.R. Squibb & Sons	F09898	D&c red no. 28; Lactose, unspecified form; D&c yellow no. 10; D&c red no. 33; Magnesium stearate; Citric acid monohydrate; Titanium dioxide; Gelatin; Sodium phosphate

Hydroxyurea 200 mg capsule

Company	Formulation ID	FDA Description
E.R. Squibb & Sons	F09896	Lactose, unspecified form; Fd&c blue no. 1; Magnesium stearate; Citric acid monohydrate; Titanium dioxide; Fd&c green no. 3; Gelatin; Sodium phosphate

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6822).
• [2] Hydroxyurea FDA Label