Details of the Drug Formulations

General Information of Drug (ID: DMP6G8T)

Drug Name
Topotecan Drug Info
Synonyms
Hycamptamine; Hycamptin; Hycamtamine; Topotecane; Topotecanum; Topotecan lactone; SKF 104864; SKF-S 104864; TOPOTECAN, HYCAMTIN; Topotecan (BAN); Topotecan [INN:BAN]; Topotecane [INN-French]; Topotecanum [INN-Latin]; Topotecan Monohydrochloride, (S)-Isomer; (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione; (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 9-Dimethylaminomethyl-10-hydroxycamptothecin
Indication
Disease Entry ICD 11 Status REF
Central nervous system neoplasm Approved [1]
Cervical cancer 2C77.0 Approved [1]
Epithelial ovarian cancer 2B5D Approved [1]
Lung cancer 2C25.0 Approved [1]
Ovarian cancer 2C73 Approved [2]
Solid tumour/cancer 2A00-2F9Z Approved [3]
Small-cell lung cancer 2C25.Y Phase 1 [4]
Neuroblastoma 2D11.2 Investigative [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
60700
ChEBI ID
CHEBI:63632
CAS Number
123948-87-8
TTD ID
D02PMO
VARIDT ID
DR00044
ACDINA ID
D00690

Full List of Drug Formulations Containing This Drug

Topotecan 0.25 mg capsule
Company Formulation ID FDA Description
Novartis Pharmaceuticals Corporation F21388 Glyceryl monostearate; Ferric oxide red; Titanium dioxide; Gelatin
GlaxoSmithKline F21389 Glyceryl monostearate; Titanium dioxide; Gelatin, unspecified
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Topotecan 1 mg capsule
Company Formulation ID FDA Description
Novartis Pharmaceuticals Corporation F21390 Glyceryl monostearate; Ferric oxide red; Titanium dioxide; Gelatin
GlaxoSmithKline F21391 Glyceryl monostearate; Ferric oxide red; Titanium dioxide; Gelatin, unspecified
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Topotecan Hydrochloride eq 4mg base/vial injectable
Company Formulation ID FDA Description
Fresenius Kabi Usa F23579 Mannito; Tartaric Acid; Hydrochloric Acid; Sodium Hydroxide
Novartis Pharmaceuticals Corporation F23578 Mannito; Tartaric Acid; Hydrochloric Acid
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Topotecan Hydrochloride eq 0.25mg base capsule
Company Formulation ID FDA Description
Novartis Pharmaceuticals Corporation F23577 Gelatin; Glyceryl Monostearate; Hydrogenated Vegetable Oil; Titanium Dioxide; Red Iron Oxide
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References

1 Topotecan FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7101).
3 Plant-derived compounds in clinical trials. Drug Discov Today. 2008 Feb;13(3-4):161-71.
4 ClinicalTrials.gov (NCT00765973) Topotecan Liposomes Injection for Small Cell Lung Cancer (SCLC), Ovarian Cancer and Other Advanced Solid Tumors. U.S. National Institutes of Health.