Details of the Drug Formulations

General Information of Drug (ID: DMS8IFC)

• Drug Name: Sorafenib Drug Info
• Synonyms: Nexavar; Sorafenibum; Sorafenib [INN]; Nexavar (TN); Sorafenib (INN); N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea; N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea; N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcar bamoyl)-4-pyridyloxy)phenyl)urea; 4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide; 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate; 4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide; 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE; Sorafenib (Pan-TK inhibitor)

Indication

Disease Entry	ICD 11	Status	REF
Adenocarcinoma	2D40	Approved	[1]
Carcinoma	2A00-2F9Z	Approved	[1]
Clear cell renal carcinoma		Approved	[1]
Lung cancer	2C25.0	Approved	[1]
Medullary thyroid gland carcinoma		Approved	[1]
Non-small-cell lung cancer	2C25.Y	Approved	[1]
Renal cell carcinoma	2C90	Approved	[2]
Thyroid cancer	2D10	Approved	[1]
Hepatocellular carcinoma	2C12.02	Phase 3	[2]
Myelodysplastic syndrome	2A37	Phase 2	[2]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 216239
  ChEBI ID: CHEBI:50924
  CAS Number: 284461-73-0
  TTD ID: D0W5HK
  VARIDT ID: DR00304
  INTEDE ID: DR1500
  ACDINA ID: D00635

Full List of Drug Formulations Containing This Drug

Sorafenib 200 mg tablet

Company	Formulation ID	FDA Description
Bayer HealthCare	F20315	Sodium lauryl sulfate; Magnesium stearate; Ferric oxide red; Titanium dioxide; Croscarmellose sodium; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols

References

• [1] Sorafenib FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5711).