Details of the Drug Formulations

General Information of Drug (ID: DMTI8YE)

Drug Name
Bosutinib Drug Info
Synonyms
SKI 606; SKI606; Bosutinib (USAN); PF-5208763; SKI-606; Xy]-3-quinolinecarbonitrile; 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-3-quinolinecarbonitrile; 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile; 4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile; 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propo; 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile; Bosutinib (BCR-ABL inhibitor 3rd gen)
Indication
Disease Entry ICD 11 Status REF
Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [1]
Breast cancer 2C60-2C65 Approved [2]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
5328940
ChEBI ID
CHEBI:39112
CAS Number
380843-75-4
TTD ID
D0OB0F
VARIDT ID
DR00253
INTEDE ID
DR0224
ACDINA ID
D00075

Full List of Drug Formulations Containing This Drug

Bosutinib Monohydrate eq 400mg base tablet
Company Formulation ID FDA Description
Pf Prism Cv F23389 Microcrystalline Cellulose; Croscarmellose Sodium; Poloxamer; Povidone; Magnesium Stearate; Polyvinyl Alcohol; Titanium Dioxide; Polyethylene Glycol; Talc; Iron Oxide Yellow; Iron Oxide Red
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Bosutinib Monohydrate eq 500mg base tablet
Company Formulation ID FDA Description
Pf Prism Cv F23387 Microcrystalline Cellulose; Croscarmellose Sodium; Poloxamer; Povidone; Magnesium Stearate; Polyvinyl Alcohol; Titanium Dioxide; Polyethylene Glycol; Talc; Iron Oxide Red
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Bosutinib Monohydrate eq 100mg base tablet
Company Formulation ID FDA Description
Pf Prism Cv F23388 Microcrystalline Cellulose; Croscarmellose Sodium; Poloxamer; Povidone; Magnesium Stearate; Polyvinyl Alcohol; Titanium Dioxide; Polyethylene Glycol; Talc; Iron Oxide Yellow
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Bosutinib 100 mg tablet
Company Formulation ID FDA Description
U.S. Pharmaceuticals F02699 Magnesium stearate; Ferric oxide yellow; Talc; Titanium dioxide; Croscarmellose sodium; Poloxamer 188; Polyethylene glycol 3350; Polyvinyl alcohol; Cellulose, microcrystalline; Povidone k25
Pfizer Laboratories F02700 Magnesium stearate; Ferric oxide yellow; Talc; Titanium dioxide; Croscarmellose sodium; Poloxamer 188; Polyethylene glycol 3350; Microcrystalline cellulose; Polyvinyl alcohol, unspecified; Povidone k25
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Bosutinib 400 mg tablet
Company Formulation ID FDA Description
Pfizer Laboratories F02701 Magnesium stearate; Ferric oxide red; Talc; Titanium dioxide; Croscarmellose sodium; Poloxamer 188; Polyethylene glycol 3350; Microcrystalline cellulose; Polyvinyl alcohol, unspecified; Povidone k25
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Bosutinib 500 mg tablet
Company Formulation ID FDA Description
Pfizer Laboratories F02702 Magnesium stearate; Ferric oxide red; Talc; Titanium dioxide; Croscarmellose sodium; Poloxamer 188; Polyethylene glycol 3350; Microcrystalline cellulose; Polyvinyl alcohol, unspecified; Povidone k25
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References

1 Bosutinib FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5710).