Details of the Drug Formulations

General Information of Drug (ID: DMVP5YE)

• Drug Name: Doxorubicin Drug Info
• Synonyms: doxorubicin; 23214-92-8; Doxil; Doxorubicine; Adriablastin; Doxorubicinum; 14-Hydroxydaunomycin; 14-Hydroxydaunorubicine; Doxorubicina; Adriamycin semiquinone; Doxorubicinum [INN-Latin]; Doxorubicine [INN-French]; Doxorubicina [INN-Spanish]; Myocet; FI 106; Doxorubicin [USAN:INN:BAN]; CCRIS 739; NDC 38242-874; HSDB 3070; UNII-80168379AG; NCI-C01514; EINECS 245-495-6; CHEMBL53463; CHEBI:28748; 5,12-Naphthacenedione,; ADM; ADR; ThermoDox; Aerosolized Doxorubicin; Doxorubicin citrate; RDF Rubex; Conjugate of doxorubicin with humanized monoclonal antibody LL1 against CD74; DM2; JT9100000; Adiblastine (hydrochloride salt); Adr iablatina (hydrochloride salt); Adriablastine (hydrochloride salt); Adriablatina (hydrochloride salt); Adriacin (hydrochloride salt); Adriamycin PFS (TN); Adriamycin PFS (hydrochloride salt); Adriamycin RDF (TN); Adriamycin RDF (hydrochloride salt); Adriblastina (TN); Adriblastina (hydrochloride salt); Adriblatina (hydrochloride salt); Caelyx (TN); Conjugate of doxorubicin with monoclonal antibody P4/D10 against GP120; DOX-SL; Doxorubicin hydrochloride (hydrochloride salt); Doxorubicin-hLL1; Doxorubicin-hLL1 conjugate; Farmablastina (hydrochloride salt); Hydroxydaunomycin hydrochlor ide (hydrochloride salt); Hydroxydaunomycin hydrochloride (hydrochloride salt); Hydroxydaunorubicin hydrochloride (hydrochloride salt); Myocet (TN); Rubex (TN); Rubex (hydrochloride salt); TLC D-99; Doxorubicin (USAN/INN); Doxorubicin-P4/D10; Doxorubicin-P4/D10 conjugate; Cantide + adriamycin

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Approved	[1] , [2]
Hepatocellular carcinoma	2C12.02	Phase 3	[3]
Breast cancer	2C60-2C65	Phase 2	[4]
Tumour	2A00-2F9Z	Investigative	[5]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 31703
  ChEBI ID: CHEBI:28748
  CAS Number: 23214-92-8
  TTD ID: D07VLY
  VARIDT ID: DR00301
  INTEDE ID: DR0546

Full List of Drug Formulations Containing This Drug

Doxorubicin Hydrochloride 20mg/10ml liposomaldispersion

Company	Formulation ID	FDA Description
Baxter Healthcare Corporation	F23722	Sodium N-Carbonyl-Methoxypolyethylene Glycol 2000-1, 2-Distearoyl-Sn-Glycero-3-Phosphoethanolamine; Cholesterol; Hydrogenated Soybean Lecithin; Ammonium Sulfate; Histidine; Hydrochloric Acid; Sodium Hydroxide; Sucrose

Doxorubicin Hydrochloride 10mg/5ml solution

Company	Formulation ID	FDA Description
Actavis Pharma	F24335	Sodium Chloride; Water; Hydrochloric Acid
Pfizer Laboratories Div Pfizer	F24334	Sodium Chloride; Hydrochloric Acid

Doxorubicin Hydrochloride 20mg/10ml solution

Company	Formulation ID	FDA Description
Actavis Pharma	F24369	Sodium Chloride; Water; Hydrochloric Acid
Pfizer Laboratories Div Pfizer	F24368	Sodium Chloride; Hydrochloric Acid

Doxorubicin Hydrochloride 50mg/25ml solution

Company	Formulation ID	FDA Description
Actavis Pharma	F24403	Sodium Chloride; Water; Hydrochloric Acid
Pfizer Laboratories Div Pfizer	F24402	Sodium Chloride; Hydrochloric Acid

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7069).
• [2] Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
• [3] ClinicalTrials.gov (NCT02112656) Study of ThermoDox With Standardized Radiofrequency Ablation (RFA) for Treatment of Hepatocellular Carcinoma (HCC) (OPTIMA). U.S. National Institutes of Health.
• [4] Antitumor activity of liposome-encapsulated doxorubicin in advanced breast cancer: phase II study. J Natl Cancer Inst. 1990 Nov 7;82(21):1706-10.
• [5] Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207.