Details of the Drug Formulations

General Information of Drug (ID: DMWT905)

Drug Name
Mefloquine Drug Info
Synonyms
Lariam; Mefloquin; Mefloquina; Mefloquinone; Mefloquinum; Mephloquine; Racemic mefloquine; Ro 215998; WR 142490; Lariam (Hydrochloride); Lariam (TN); Mefaquin (TN); Mefloquina [INN-Spanish]; Mefloquinum [INN-Latin]; RO 13-7224; RO 13-7225; Ro 21-5998; SPB-80406; WR-142490; Mefloquine (USAN/INN); Mefloquine [USAN:INN:BAN]; RTI1169-1-1; RTI1172-1-1; RTI1173-1-1; RTI1174-1-1; RTI1188-1-1; RTI1189-1-1; Ro 21-5998 (Hydrochloride); WR-142,490; WR-177,602; Ro-21-5998-001; Alpha-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol; Alpha-2-Piperidyl-2,8-bis(trifluoromethyl)quinoline-4-methanol; [2,8-bis(trifluoromethyl)quinolin-4-yl]-piperidin-2-ylmethanol; Erthro-.alpha.-[2-piperidyl]-2,8-bis[trifluoromethyl]-4-quinolinemethanol; (+)-(11R,2'S)-erythro-Mefloquine; (+)-Mefloquine; (+)-Threo-Mefloquine; (-)-(11S,2'R)-erythro-Mefloquine; (-)-Mefloquine; (-)-Threo-Mefloquine; (DL-erythro-alpha-2-Piperidyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol; (R)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2R)-piperidin-2-yl]methanol; (R)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2S)-piperidin-2-yl]methanol; (S)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2R)-piperidin-2-yl]methanol; (S)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2S)-piperidin-2-yl]methanol; (S)-[2,8-bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol
Indication
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [2]
Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [3]
Severe acute respiratory syndrome (SARS) 1D65 Preclinical [3]
Progressive multifocal leukoencephalopathy 8A45.02 Investigative [4]
Therapeutic Class
Antimalarials
Cross-matching ID
PubChem CID
4046
ChEBI ID
CHEBI:63681
CAS Number
49752-90-1
TTD ID
D0GQ7K
VARIDT ID
DR00623
INTEDE ID
DR1016
ACDINA ID
D00391

Full List of Drug Formulations Containing This Drug

Mefloquine 250 mg tablet
Company Formulation ID FDA Description
Rebel Distributors; West-Ward Pharmaceticals F12849 Lactose monohydrate; Magnesium stearate; Talc; Crospovidone; Polysorbate 80; Povidone k30; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
A-S Medication Solutions F12848 Lactose monohydrate; Magnesium stearate; Talc; Crospovidone; Poloxamer 188; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
H. J. Harkins Company F12844 Lactose monohydrate; Magnesium stearate; Talc; Crospovidone; Polysorbate 80; Povidone k30; Cellulose, microcrystalline; Colloidal silicon dioxide; Starch, corn
Preferred Pharamaceuticals F12846 Lactose monohydrate; Magnesium stearate; Talc; Poloxamer 188; Silicon dioxide; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%); Starch, corn
Teva Pharmaceuticals F12847 Lactose monohydrate; Magnesium stearate; Talc; Poloxamer 188; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Microcrystalline cellulose; Starch, corn
Rebel Distributors F12850 Lactose monohydrate; Magnesium stearate; Talc; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Poloxamer 124; Starch, corn; Starch, corn
Physicians Total Care; Sandoz F12843 Lactose monohydrate; Magnesium stearate; Talc; Crospovidone; Cellulose, microcrystalline; Hydroxypropyl cellulose, low substituted; Starch, corn
West-Ward Pharmaceticals F12845 Lactose monohydrate; Magnesium stearate; Calcium alginate; Silicon dioxide; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%); Poloxamer 331; Povidone k29/32; Propylene glycol alginate; Starch, corn
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References

1 FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (NDA) 019578
2 ClinicalTrials.gov (NCT04347031) An Open Randomized Study of the Effectiveness of Mefloquine for the Treatment of Patients With COVID19. U.S. National Institutes of Health.
3 Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. Antimicrob Agents Chemother. 2014 Aug;58(8):4885-93.
4 Mefloquine FDA Label