Details of the Drug Formulations

General Information of Drug (ID: DMXBLMP)

• Drug Name: Riociguat Drug Info
• Synonyms: Riociguat; 625115-55-1; Adempas; Riociguat (BAY 63-2521); BAY 63-2521; riociguatum; UNII-RU3FE2Y4XI; RU3FE2Y4XI; CHEBI:76018; Methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate; Methyl N-(4,6-diamino-2-{1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate; N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methylcarbamic acid methyl ester

Indication

Disease Entry	ICD 11	Status	REF
Chronic thromboembolic pulmonary hypertension		Approved	[1]
Pulmonary arterial hypertension	BB01.0	Approved	[2]

• Cross-matching ID:
  PubChem CID: 11304743
  ChEBI ID: CHEBI:76018
  CAS Number: 625115-55-1
  TTD ID: D04UKC
  VARIDT ID: DR00080
  INTEDE ID: DR1427
  ACDINA ID: D00597

Full List of Drug Formulations Containing This Drug

Riociguat 2 mg tablet

Company	Formulation ID	FDA Description
Bayer HealthCare	F19010	Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Propylene glycol; Titanium dioxide; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%); Hydroxypropyl cellulose (type h); Hypromelloses

Riociguat 2.5 mg tablet

Company	Formulation ID	FDA Description
Bayer HealthCare	F19011	Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Propylene glycol; Titanium dioxide; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%); Hydroxypropyl cellulose (type h); Hypromelloses

Riociguat 1 mg tablet

Company	Formulation ID	FDA Description
Bayer HealthCare	F19008	Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Ferric oxide yellow; Propylene glycol; Titanium dioxide; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%); Hydroxypropyl cellulose (type h); Hypromelloses

Riociguat 1.5 mg tablet

Company	Formulation ID	FDA Description
Bayer HealthCare	F19009	Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Ferric oxide yellow; Propylene glycol; Titanium dioxide; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%); Hydroxypropyl cellulose (type h); Hypromelloses

Riociguat 0.5 mg tablet

Company	Formulation ID	FDA Description
Bayer HealthCare	F19007	Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Propylene glycol; Titanium dioxide; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%); Hydroxypropyl cellulose (type h); Hypromelloses

References

• [1] Riociguat FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5257).