Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM0AQ83)

Drug Name
Emicizumab Drug Info
Indication
Disease Entry ICD 11 Status REF
Factor VIII deficiency 3B10 Approved [1]
Cross-matching ID
TTD Drug ID
DM0AQ83

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Coagulation factor IX (F9) TTFEZ5Q FA9_HUMAN Modulator [1]
Coagulation factor Xa (F10) TTCIHJA FA10_HUMAN Modulator [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Coagulation factor IX (F9) DTT F9 11.652 4.365 4.591 4.667
Coagulation factor Xa (F10) DTT F10 7.763 4.672 3.248 4.609
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Factor VIII deficiency
ICD Disease Classification 3B10
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Coagulation factor Xa (F10) DTT F10 4.84E-02 -0.28 -0.9
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.