Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM0AZLE)

Drug Name

WY-46016 Drug Info

Synonyms

104325-55-5; 3-(2-Quinolinylmethoxy)benzeneacetic acid; Wy-46016; WY-46,016; AC1L2TZC; 2-[3-(quinolin-2-ylmethoxy)phenyl]acetic acid; [3-(Quinolin-2-ylmethoxy)-phenyl]-acetic acid; CHEMBL310611; SCHEMBL9053241; CTK8G4858; DTXSID00146391; VTTJDSVAGYOMKY-UHFFFAOYSA-N; ZINC5162878; 3-(2-Quinolinylmethoxy)phenylacetic acid; 3-[(2-Quinolinyl)methoxy]benzeneacetic acid; Benzeneacetic acid, 3-(2-quinolinylmethoxy)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 128543
CAS Number: CAS 104325-55-5
TTD Drug ID: DM0AZLE

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Leukotriene CysLT1 receptor (CYSLTR1)	TTGKOY9	CLTR1_HUMAN	Modulator	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Leukotriene CysLT1 receptor (CYSLTR1)	DTT	CYSLTR1	3.233	3.733	-0.152	3.797

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Leukotriene CysLT1 receptor (CYSLTR1)	DTT	CYSLTR1	1.96E-02	0.24	0.43

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	N-[(arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides.Potent orally active leukotriene D4 antagonists of novel structure.J Med Chem.1990 Jan;33(1):240-5.