Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM0BCT7)

Drug Name
DTRI-031 Drug Info
Synonyms BB-031
Indication
Disease Entry ICD 11 Status REF
Ischemic stroke 8B11.5Z Phase 1 [1]
Cross-matching ID
TTD Drug ID
DM0BCT7

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
von Willebrand factor (VWF) TT3SZBT VWF_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
von Willebrand factor (VWF) DTT VWF 3.459 8.185 6.67 8.541
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Ischemic stroke
ICD Disease Classification 8B11.5Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
von Willebrand factor (VWF) DTT VWF 2.96E-01 2.47 2.08
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT05005520) A Randomized, Double-Blind, Single-Center, Placebo-Controlled Phase 1 Study to Evaluate the Safety, Tolerability, PK and PD of Intravenous DTRI-031 in Healthy Volunteers. U.S.National Institutes of Health.
2 Clinical pipeline report, company report or official report of Basking Biosciences