Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM0C1IX)

• Drug Name: Anti-MUC1 CAR T Cells Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Phase 1/2	[1]
Hepatocellular carcinoma	2C12.02	Phase 1/2	[1]
Lung cancer	2C25.0	Phase 1/2	[2]
Non-small-cell lung cancer	2C25.Y	Phase 1/2	[2]
Pancreatic cancer	2C10	Phase 1/2	[1]

• Cross-matching ID: TTD Drug ID: DM0C1IX

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mucin-1 (MUC1)	TTBHFYQ	MUC1_HUMAN	CAR-T-Cell-Therapy	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Mucin-1 (MUC1)	DTT	MUC1	3.485	8.525	9.106	5.714
Mucin-1 (MUC1)	DTT	MUC1	3.485	8.525	9.106	5.714

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Breast cancer
• ICD Disease Classification: 2C60-2C65

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Mucin-1 (MUC1)	DTT	MUC1	4.59E-01	-0.07	-0.41

References

• [1] ClinicalTrials.gov (NCT02587689) Phase I/II Study of Anti-Mucin1 (MUC1) CAR T Cells for Patients With MUC1+ Advanced Refractory Solid Tumor
• [2] ClinicalTrials.gov (NCT03525782) Anti-MUC1 CAR T Cells and PD-1 Knockout Engineered T Cells for NSCLC