Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM0ILRU)

Drug Name

RDEA-436 Drug Info

Synonyms

MEK inhibitor, Ardea; MEK inhibitor (cancer), Bayer; MEK inhibitor 200 series (cancer), Bayer HealthCare; MEK inhibitor 200 series (inflammation), Ardea; Mitogen-activated ERK kinase inhibitor (inflammation), Ardea; RDEA-436 (cancer), Bayer HealthCare; RDEA-436 (cancer/inflammation), Ardea

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 1	[1]

Cross-matching ID

TTD Drug ID: DM0ILRU

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
ERK activator kinase 1 (MEK1)	TTIDAPM	MP2K1_HUMAN	Inhibitor	[2]
ERK activator kinase 2 (MEK2)	TTTW2NY	MP2K2_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
ERK activator kinase 2 (MEK2)	DTT	MAP2K2	4.372	6.068	6.352	6.894
ERK activator kinase 1 (MEK1)	DTT	MAP2K1	8.617	7.493	7.334	6.969

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Solid tumour/cancer

ICD Disease Classification

2A00-2F9Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
ERK activator kinase 2 (MEK2)	DTT	MAP2K2	2.46E-03	-0.71	-2.42
ERK activator kinase 1 (MEK1)	DTT	MAP2K1	6.84E-01	0.03	0.2

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028258)
2	Clinical pipeline report, company report or official report of MedKoo Biosciences.