Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM0NEVC)

Drug Name
Indole-based analog 2 Drug Info
Synonyms PMID27744724-Compound-16
Cross-matching ID
TTD Drug ID
DM0NEVC

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Apoptosis regulator Bcl-2 (BCL-2) TTJGNVC BCL2_HUMAN Inhibitor [1]
Apoptosis regulator Bcl-xL (BCL-xL) TTU1E82 B2CL1_HUMAN Inhibitor [1]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) TTL53M6 MCL1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Apoptosis regulator Bcl-xL (BCL-xL) DTT BCL2L1 4.863 5.664 6.092 5.843
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DTT MCL1 7.695 6.404 5.954 6.82
Apoptosis regulator Bcl-2 (BCL-2) DTT BCL2 3.963 4.739 4.146 4.878
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Apoptosis regulator Bcl-xL (BCL-xL) DTT BCL2L1 7.28E-13 -0.55 -0.68
Apoptosis regulator Bcl-2 (BCL-2) DTT BCL2 9.45E-01 1.35E-02 0.05
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178.