Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM0TH9A)

Drug Name
Bimosiamose Drug Info
Synonyms TBC 1269; TBC-1269
Indication
Disease Entry ICD 11 Status REF
Atopic dermatitis EA80 Phase 2a [1]
Chronic obstructive pulmonary disease CA22 Phase 2a [1]
Psoriatic disorder EA90 Phase 2a [1]
Asthma CA23 Phase 2 [1]
Cross-matching ID
PubChem CID
9811353
CAS Number
CAS 187269-40-5
TTD Drug ID
DM0TH9A

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
E-selectin (SELE) TTAU4D6 LYAM2_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
E-selectin (SELE) DTT SELE 5.194 3.307 3.104 5.907
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Atopic dermatitis
ICD Disease Classification EA80
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
E-selectin (SELE) DTT SELE 6.43E-04 0.02 0.12
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Emerging drugs for asthma. Expert Opin Emerg Drugs. 2008 Dec;13(4):643-53.
2 Effects of the pan-selectin antagonist bimosiamose (TBC1269) in experimental human endotoxemia. Shock. 2008 Apr;29(4):475-82.