Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM129T7)

Drug Name
CROMOGLYCATE LISETIL HYDROCHLORIDE Drug Info
Synonyms Diethyl L-lysylcromoglycate dihydrochloride; KY-556; N-556; Cromoglycate lisetil hydrochloride
Indication
Disease Entry ICD 11 Status REF
Asthma CA23 Phase 2 [1]
Cross-matching ID
PubChem CID
196639
ChEBI ID
CHEBI:31438
CAS Number
CAS 110816-79-0
TTD Drug ID
DM129T7

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Calcium-activated potassium channel KCa1.1 (KCNMA1) TTE87WJ KCMA1_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Calcium-activated potassium channel KCa1.1 (KCNMA1) DTT KCNMA1 4.492 4.828 4.973 4.426
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Asthma
ICD Disease Classification CA23
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Calcium-activated potassium channel KCa1.1 (KCNMA1) DTT KCNMA1 4.48E-03 0.19 0.7
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT01722812) Cromoglicate in Psoriasis. U.S. National Institutes of Health.
2 The significance of chloride in the inhibitory action of disodium cromoglycate on immunologically-stimulated rat peritoneal mast cells. Biochim Biophys Acta. 2011 Sep;1810(9):867-74.