Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM180VX)

Drug Name

SC-49483 Drug Info

Synonyms

Glycovir; 131262-82-3; UNII-QXJ91425UL; DRG-0193; NSC 670880; Perbutylated-N-butyl-1-deoxynojiromycin; SC 49483; QXJ91425UL; N-Butyl DNJ Prodrug; Butanoic acid, 1-butyl-2-((1-oxobutoxy)methyl)-3,4,5-piperidinetriyl ester, (2R-(2alpha,3beta,4alpha,5beta))-; SC-48334 Prodrug; NSC670880; SC49483; AC1L1TYK; 1,5-(Butylimino)-1-5-dideoxy-D-glucitol tetrabutanoate; AC1Q60AI; SCHEMBL5967912; DTXSID10156986; NSC-670880; DB13106; LS-46130; 1-Butyl-2R,4.alpha.,5.beta.-piperidinetriyl butanoate

Indication

Disease Entry	ICD 11	Status	REF
Acquired immune deficiency syndrome	1C62.3	Phase 2	[1]

Cross-matching ID

PubChem CID: 60807
CAS Number: CAS 131262-82-3
TTD Drug ID: DM180VX

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Intestinal maltase-glucoamylase (MGAM)	TTXWASR	MGA_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Acquired immune deficiency syndrome

ICD Disease Classification

1C62.3

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Intestinal maltase-glucoamylase (MGAM)	DTT	MGAM	4.59E-01	-0.02	-0.24

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT00000791) A Phase II Double-Blind Study of Two Doses of SC-49483 in Combination With Zidovudine (ZDV) Versus ZDV. U.S. National Institutes of Health.
2	Pathology of perbutylated-N-butyl-1-deoxynojiromycin (an alpha-glucosidase-1 inhibitor) in Sprague-Dawley rats. Toxicol Pathol. 1996 Sep-Oct;24(5):531-8.