Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM18E9D)

• Drug Name: (1R,2R)-1,2-diphenylethane-1,2-diamine Drug Info
• Synonyms: 35132-20-8; (1R,2R)-(+)-1,2-Diphenylethylenediamine; (1R,2R)-rel-1,2-Diphenylethane-1,2-diamine; (1R,2R)-1,2-Diphenylethylenediamine; 16635-95-3; (+)-1,2-diphenylethylenediamine; MFCD00082769; (+)-STILBENEDIAMINE; (R,R)-DPEN; (r,r)-(+)-1,2-diphenylethylenediamine; CHEMBL381340; (1r,2r)-1,2-diphenyl-ethane-1,2-diamine; 1,2-Ethanediamine, 1,2-diphenyl-, (1R,2R)-; (1R,2R)-(+)-1,2-Diphenyl-1,2-ethane diam

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 2724998
  CAS Number: CAS 35132-20-8
  TTD Drug ID: DM18E9D

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dipeptidyl peptidase 4 (DPP-4)	TTDIGC1	DPP4_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Dipeptidyl peptidase 4 (DPP-4)	DTT	DPP4	4.995	4.926	7.852	8.358

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dipeptidyl peptidase 4 (DPP-4)	DTT	DPP4	9.54E-01	-0.27	-1.85

References

• [1] In silico fragment-based discovery of DPP-IV S1 pocket binders. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1405-9.