Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1CZSJ)

Drug Name

(+)-JQ1 Drug Info

Synonyms

1268524-70-4; (+)-JQ-1; JQ1 compound; (+)-JQ1; JQ-1; UNII-1MRH0IMX0W; (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate; (S)-JQ1; 1MRH0IMX0W; JQ1; CHEMBL1957266; AK109409; (S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate; (S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepin-6-yl)acetate; (S)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3

Indication

Disease Entry	ICD 11	Status	REF
Testicular cancer	2C80	Phase 1	[1]

Cross-matching ID

PubChem CID: 46907787
ChEBI ID: CHEBI:95080
CAS Number: CAS 1268524-70-4
TTD Drug ID: DM1CZSJ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bromodomain and extraterminal domain protein (BET)	TTE4BSY	NOUNIPROTAC	Inhibitor	[1]
Bromodomain testis-specific protein (BRDT)	TT7CPI5	BRDT_HUMAN	Inhibitor	[2]
Bromodomain-containing protein 4 (BRD4)	TTRA6BO	BRD4_HUMAN	Inhibitor	[3]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Bromodomain-containing protein 4 (BRD4)	DTT	BRD4	6.686	6.622	6.963	6.725
Bromodomain testis-specific protein (BRDT)	DTT	BRDT	3.322	-0.322	2.433	1.678

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Testicular cancer

ICD Disease Classification

2C80

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Bromodomain-containing protein 4 (BRD4)	DTT	BRD4	3.27E-01	0.02	0.04
Bromodomain testis-specific protein (BRDT)	DTT	BRDT	2.39E-01	0.02	0.14

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Small-molecule inhibition of BRDT for male contraception. Cell. 2012 Aug 17;150(4):673-84.
3	Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.