Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1GYZQ)

• Drug Name: Pyrrolo[2,3-d]pyrimidine derivative 16 Drug Info
• Synonyms: PMID28705083-Compound-14

Indication

Disease Entry	ICD 11	Status	REF
Autoimmune disease	4A40-4A45	Patented	[1]
Solid tumour/cancer	2A00-2F9Z	Patented	[1]

• Cross-matching ID:
  PubChem CID: 89188538
  TTD Drug ID: DM1GYZQ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tyrosine-protein kinase BTK (ATK)	TTGM6VW	BTK_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tyrosine-protein kinase BTK (ATK)	DTT	BTK	3.838	3.897	5.053	5.897

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Autoimmune disease
• ICD Disease Classification: 4A40-4A45

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tyrosine-protein kinase BTK (ATK)	DTT	BTK	3.54E-01	0.24	0.56

References

• [1] Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318.