Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1I6AY)

Drug Name

PMID18334293C15b Drug Info

Synonyms

Scios-15b; GTPL8157; BDBM50374977

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
CaM-kinase II (CAMK2)	TTFYL58	KCC2A_HUMAN; KCC2B_HUMAN; KCC2D_HUMAN; KCC2G_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
CaM-kinase II (CAMK2)	DTT	CAMK2A	5.567	3.162	4.85	3.945

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
CaM-kinase II (CAMK2)	DTT	CAMK2A; CAMK2B; CAMK2D; CAMK2G	1.34E-02	-0.33	-0.93

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Pyrimidine-based inhibitors of CaMKIIdelta. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2404-8.