Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1KBSV)

Drug Name
Macrocycle derivative 13 Drug Info
Synonyms PMID28270010-Compound-Figure21-a
Indication
Disease Entry ICD 11 Status REF
Cell proliferative disorder FB86 Patented [1]
Cross-matching ID
PubChem CID
123787452
TTD Drug ID
DM1KBSV

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
BDNF/NT-3 growth factors receptor (TrkB) TTKN7QR NTRK2_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
BDNF/NT-3 growth factors receptor (TrkB) DTT NTRK2 4.65 5.231 6.555 4.672
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Cell proliferative disorder
ICD Disease Classification FB86
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
BDNF/NT-3 growth factors receptor (TrkB) DTT NTRK2 3.06E-01 -0.15 -0.31
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751.