Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1TNWG)

Drug Name

1-propionyl-1H-indole-2,3-dione Drug Info

Synonyms

1-Propionyl-1H-indole-2,3-dione; 17529-69-0; 1-propanoyl-2,3-dihydro-1H-indole-2,3-dione; Propionylisatin; Isatin-based compound, 9; AC1LBV75; 1-propanoylindole-2,3-dione; CHEMBL386000; BDBM22789; MolPort-002-488-122; IHNYAHBLLCMRCD-UHFFFAOYSA-N; ZINC3086180; ZX-AN080727; ALBB-029917; AKOS001849000; 1-Propionyl-1H-indole-2,3-dione #; MCULE-1099895518; CCG-139392; 1H-Indole-2,3-dione, 1-(1-oxopropyl)-; EU-0084456; 1H-Isoindole-2,3(2H)-dione, 1-propionyl-; SR-01000512691

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 589576
TTD Drug ID: DM1TNWG

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Liver carboxylesterase (CES1)	TTMF541	EST1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Liver carboxylesterase (CES1)	DTT	CES1	12.04	6.525	5.311	5.909

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Liver carboxylesterase (CES1)	DTT	CES1	3.82E-08	1.86	1.9

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85.