Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1YEPS)

Drug Name

Volanesorsen Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Hypertriglyceridemia	5C80.1	Approved	[1]
Hyperlipoproteinemia	5C80	Phase 3	[2]
Familial chylomicronemia syndrome	5C80	Phase 1	[3]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
ApoC-III messenger RNA (APOC3 mRNA)	TTXOZQ1	APOC3_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
ApoC-III messenger RNA (APOC3 mRNA)	DTT	APOC3	12.577	4.597	2.293	10.581

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Hypertriglyceridemia

ICD Disease Classification

5C80.1

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
ApoC-III messenger RNA (APOC3 mRNA)	DTT	APOC3	2.67E-01	0.1	0.59

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Metabolism and Disposition of Volanesorsen, a 2'- O-(2 methoxyethyl) Antisense Oligonucleotide, Across Species. Drug Metab Dispos. 2019 Oct;47(10):1164-1173.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8681).
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)