Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM20CIM)

Drug Name
RNF43-721 Drug Info
Synonyms RNF43-721/Montanide ISA51; Peptide vaccine (subcutaneous, colorectal cancer), Tokyo Women's Medical College
Indication
Disease Entry ICD 11 Status REF
Colorectal cancer 2B91.Z Phase 2 [1]
Cross-matching ID
TTD Drug ID
DM20CIM

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
RING finger protein 43 (RNF43) TTD91BL RNF43_HUMAN Modulator [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
RING finger protein 43 (RNF43) DTT RNF43 5.285 6.672 5.472 7.025
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Colorectal cancer
ICD Disease Classification 2B91.Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
RING finger protein 43 (RNF43) DTT RNF43 2.79E-04 1.13 3.02
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Phase I clinical trial of a novel peptide vaccine in combination with UFT/LV for metastatic colorectal cancer. Exp Ther Med. 2011 Jan-Feb; 2(1): 73-79.