Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM2570B)

Drug Name
Poly-ICLC Drug Info
Indication
Disease Entry ICD 11 Status REF
Glioblastoma multiforme 2A00.0 Phase 2 [1]
Solid tumour/cancer 2A00-2F9Z Phase 2 [2]
Recurrent glioblastoma 2A00.00 Phase 1/2 [2]
Cross-matching ID
PubChem CID
136033680
TTD Drug ID
DM2570B

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Toll-like receptor 3 (TLR3) TTD24Y0 TLR3_HUMAN Inducer [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Toll-like receptor 3 (TLR3) DTT TLR3 4.256 5.833 5.916 6.583
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Glioblastoma multiforme
ICD Disease Classification 2A00.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Toll-like receptor 3 (TLR3) DTT TLR3 4.85E-01 0.63 0.83
Toll-like receptor 3 (TLR3) DTT TLR3 8.00E-01 0.11 0.1
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models. J Transl Med. 2007 Feb 12;5:10.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)