Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM26SE7)

Drug Name

TAM-67 Drug Info

Synonyms

CHEMBL16410; UNII-929J96FO8T; 82668-33-5; JPC-211; U-99194A maleate; 929J96FO8T; PNU-99194A free base; 5,6-dimethoxy-n,n-dipropylindan-2-amine; JPC 211; Tocris-1357; NCGC00016073-01; 2-Di-n-propylamino-5,6-dimethoxyindane; Lopac-U-116; 1H-Inden-2-amine, 2,3-dihydro-5,6-dimethoxy-N,N-dipropyl-; AC1L1KRQ; Biomol-NT_000031; AC1Q56MX; Lopac0_001207; ZINC7459; SCHEMBL2640137; BPBio1_001223; CHEBI:93232; DTXSID50274471; BDBM50107876; CCG-205281; PNU-99,194; API0008965; NCGC00025123-03; NCGC00025123-01; NCGC00016073-02

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5626
ChEBI ID: CHEBI:93232
CAS Number: CAS 82668-33-5
TTD Drug ID: DM26SE7

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transcription factor AP-1 (JUN)	TTN3GBV	JUN_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Transcription factor AP-1 (JUN)	DTT	JUN	7.311	6.659	6.272	7.023

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Transcription factor AP-1 (JUN)	DTT	JUN	1.13E-03	0.92	1.87

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	AP-1 blockade inhibits the growth of normal and malignant breast cells. Oncogene. 2001 May 17;20(22):2771-80.