Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM27GZC)

• Drug Name: 2-PMPA Drug Info
• Synonyms: 2-(Phosphonomethyl)pentanedioic acid; 2-(phosphonomethyl)pentanedioic acid; 173039-10-6; PMPA (NAALADase inhibitor); CHEMBL47009; 2-(PHOSPHONOMETHYL)-PENTANEDIOIC ACID; PMPA(NAALADaseinhibitor); 2-PMPA(NAALADaseinhibitor); SCHEMBL383173; BDBM17659; KS-00001CPM; CTK0E4395; DTXSID90436036; MolPort-023-276-085; ISEYJGQFXSTPMQ-UHFFFAOYSA-N; HMS3267D10; 2-Phosphonomethyl-pentanedioic acid; EX-A1248; pentanedioic acid analogue, (RS)-1; ANW-62579; AKOS016004257; API0001123; 2-PMPA, > MP-2042; CS-6202; Pentanedioic acid, 2-(phosphonomethyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 10130754
  CAS Number: CAS 173039-10-6
  TTD Drug ID: DM27GZC

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate carboxypeptidase II (GCPII)	TT9G4N0	FOLH1_HUMAN	Inhibitor	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glutamate carboxypeptidase II (GCPII)	DTT	FOLH1	6.894	4.758	5.651	9.837

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glutamate carboxypeptidase II (GCPII)	DTT	FOLH1	1.40E-09	2.08	2.21

References

• [1] Design and synthesis of a siderophore conjugate as a potent PSMA inhibitor and potential diagnostic agent for prostate cancer. Bioorg Med Chem. 2008 Feb 15;16(4):1648-57.
• [2] Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury. Nat Med. 1999 Dec;5(12):1396-402.