Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM2F1T0)

Drug Name	PMID25435179-Compound-WO2012106509CAY10602 Drug Info
Cross-matching ID	TTD Drug ID DM2F1T0

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
NAD-dependent deacetylase sirtuin-1 (SIRT1)	TTUF2HO	SIR1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
NAD-dependent deacetylase sirtuin-1 (SIRT1)	DTT	SIRT1	6.202	6.863	6.331	6.61

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
NAD-dependent deacetylase sirtuin-1 (SIRT1)	DTT	SIRT1	7.25E-01	-0.06	-0.16
NAD-dependent deacetylase sirtuin-1 (SIRT1)	DTT	SIRT1	2.92E-05	-0.25	-0.64

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15.