Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM2IDQ9)

Drug Name
RG-7103 Drug Info
Synonyms R-7103; RO-5024118; VPAC2 agonist (COPD), Roche
Indication
Disease Entry ICD 11 Status REF
Chronic obstructive pulmonary disease CA22 Phase 1 [1]
Cross-matching ID
PubChem CID
90871060
CAS Number
CAS 1001080-55-2
TTD Drug ID
DM2IDQ9

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Helodermin-preferring VIP receptor (VIPR2) TT4O5P0 VIPR2_HUMAN Agonist [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Helodermin-preferring VIP receptor (VIPR2) DTT VIPR2 1.632 3.888 3.293 3.087
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 12 Disease of the respiratory system
Disease Class ICD-11: CA23 Asthma
The Studied Tissue Lung tissue
The Studied Disease Chronic obstructive pulmonary disease [ICD-11:CA23]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Helodermin-preferring VIP receptor (VIPR2) DTT VIPR2 1.54E-01 -0.08 -0.4
Helodermin-preferring VIP receptor (VIPR2) DTT VIPR2 6.31E-01 6.73E-03 0.03
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT01009424) A Multi-center Study to Investigate the Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of R7103 Following Repeated Inhalation in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease. U.S. National Institutes of Health.
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027925)