Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM2LHPU)

Drug Name

ZK-200775 Drug Info

Synonyms

Fanapanel; MPQX; 161605-73-8; ZK 200775; ZK200775; Fanapanel [INN]; UNII-E3AP71EM0O; ZK-200775; E3AP71EM0O; NCGC00159553-01; [7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-4H-quinoxalin-1-yl]methylphosphonic acid; DSSTox_RID_81332; DSSTox_CID_26093; DSSTox_GSID_46093; ((3,4-Dihydro-7-morpholino-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl)methyl)phosphonic acid; {[7-Morpholin-4-Yl-2,3-Dioxo-6-(Trifluoromethyl)-3,4-Dihydroquinoxalin-1(2h)-Yl]methyl}phosphonic Acid; CAS-161605-73-8; C14H15F3N3O6P; ZK1; AC1L4LOG; AC1Q6RR4

Indication

Disease Entry	ICD 11	Status	REF
Coronary artery disease	BA80	Phase 1	[1]

Cross-matching ID

PubChem CID: 208953
CAS Number: CAS 161605-73-8
TTD Drug ID: DM2LHPU

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor AMPA (GRIA)	TTAN6JD	NOUNIPROTAC	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glutamate receptor AMPA (GRIA)	DTT	GRIA	3.07	2.907	2.945	3.485

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Coronary artery disease

ICD Disease Classification

BA80

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glutamate receptor AMPA (GRIA)	DTT	NO-GeName	1.79E-04	-0.69	-0.58

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7636).
2	Synthesis of anticonvulsive AMPA antagonists: 4-oxo-10-substituted-imidaz. Bioorg Med Chem Lett. 2001 May 7;11(9):1205-10.