Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM2QIN1)

Drug Name

HT-100 Drug Info

Synonyms

Halofunginone

Indication

Disease Entry	ICD 11	Status	REF
Duchenne dystrophy	8C70	Phase 2	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bifunctional aminoacyl-tRNA synthetase (EPRS)	TTXYCDZ	SYEP_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Bifunctional aminoacyl-tRNA synthetase (EPRS)	DTT	EPRS	6.311	6.223	7.295	7.226

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Duchenne dystrophy

ICD Disease Classification

8C70

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Bifunctional aminoacyl-tRNA synthetase (EPRS)	DTT	EPRS	1.16E-05	-0.56	-1.7

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT02525302) HT-100 Long-term Study in DMD Patients Who Completed HALO-DMD-02.
2	Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol. 2012 Feb 12;8(3):311-7.