Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM2R94W)

Drug Name
PMID21536437C15c Drug Info
Synonyms GTPL8553; BDBM50345537
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
54585928
TTD Drug ID
DM2R94W

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aggrecanase (ADAMTS5) TTXSU2Y ATS5_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Aggrecanase (ADAMTS5) DTT ADAMTS5 5.527 6.073 5.885 6.287
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Aggrecanase (ADAMTS5) DTT ADAMTS5 6.40E-01 0.24 0.26
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3301-6.