Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM2VC0E)

Drug Name

8-prenylapigenin Drug Info

Synonyms

Licoflavone C; 8-Prenylapigenin; 72357-31-4; UNII-0DQ85982ZY; 4',5,7-Trihydroxy-8-prenylflavone; CHEMBL371562; 0DQ85982ZY; SCHEMBL1231403; MEGxp0_002023; ACon1_001079; ZINC21406; MolPort-001-742-698; 4,5,7-trihydroxy-8-prenylflavone; LMPK12110422; BDBM50240972; 5,7,4'-Trihydroxy-8-prenylflavone; AKOS027326549; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-; NCGC00169697-01; BRD-K74687851-001-01-8

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10246505
CAS Number: CAS 72357-31-4
TTD Drug ID: DM2VC0E

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 5A (PDE5A)	TTJ0IQB	PDE5A_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Phosphodiesterase 5A (PDE5A)	DTT	PDE5A	3.632	3	3.632	4.271

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Phosphodiesterase 5A (PDE5A)	DTT	PDE5A	1.60E-01	-0.25	-0.99

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J Nat Prod. 2008 Sep;71(9):1513-7.