Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM30RNY)

Drug Name

2,5-bis(4-methoxyphenyl)thiophene Drug Info

Synonyms

2,5-bis(4-methoxyphenyl)thiophene; CHEMBL378797; 55827-09-3; AC1MS3AA; SCHEMBL1181273; CTK1F5890; DTXSID30393578; SNVBIBDQUGLRIV-UHFFFAOYSA-N; ZINC405078; BDBM50178543; AKOS024342405; MCULE-5357210093; Thiophene, 2,5-bis(4-methoxyphenyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3552928
CAS Number: CAS 55827-09-3
TTD Drug ID: DM30RNY

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Amyloid beta A4 protein (APP)	TTE4KHA	A4_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Amyloid beta A4 protein (APP)	DTT	APP	6.473	8.014	8.631	7.57

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Amyloid beta A4 protein (APP)	DTT	APP	1.60E-02	-0.07	-0.31

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1350-2.