General Information of Drug (ID: DM31V7K)

Drug Name
VU10007 Drug Info
Synonyms (S)-3-Amino-4,6-dimethyl-N-(1-phenylethyl)thieno[2,3-b]pyridine-2-carboxamide 2,2,2-trifluoroacetate; VU10007; AC1LEQT2; CHEMBL1212991; ZINC61353
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
690842
TTD Drug ID
DM31V7K

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Muscarinic acetylcholine receptor M4 (CHRM4) TTQ3JTF ACM4_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Muscarinic acetylcholine receptor M4 (CHRM4) DTT CHRM4 6.227 5.863 5.776 5.567
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Muscarinic acetylcholine receptor M4 (CHRM4) DTT CHRM4 1.93E-01 -0.08 -0.27
Muscarinic acetylcholine receptor M4 (CHRM4) DTT CHRM4 1.62E-01 -0.11 -0.63
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nat Chem Biol. 2008 Jan;4(1):42-50.