Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3786U)

Drug Name
F-12509A Drug Info
Indication
Disease Entry ICD 11 Status REF
Arteriosclerosis BD40 Terminated [1]
Cross-matching ID
PubChem CID
9862964
TTD Drug ID
DM3786U

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sphingosine kinase 1 (SPHK1) TTOHFIY SPHK1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Sphingosine kinase 1 (SPHK1) DTT SPHK1 6.441 6.18 5.508 5.845
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Arteriosclerosis
ICD Disease Classification BD40
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Sphingosine kinase 1 (SPHK1) DTT SPHK1 7.48E-01 -0.01 -0.06
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 F-12509A, a new sphingosine kinase inhibitor, produced by a discomycete. J Antibiot (Tokyo). 2000 May;53(5):459-66.