Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3FP6J)

Drug Name

1-(3-nitropyridin-2-yl)-4-tosylpiperazine Drug Info

Synonyms

AC1PKJ5N; arylsulfonylpiperazine, 26; CHEMBL257825; BDBM32554; MolPort-005-603-659; 1-(4-methylphenyl)sulfonyl-4-(3-nitropyridin-2-yl)piperazine; ZINC24082236; AKOS034151568; MCULE-2914079043; AB00774122-01; Z31097365; 1-(4-methylbenzenesulfonyl)-4-(3-nitropyridin-2-yl)piperazine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9111347
TTD Drug ID: DM3FP6J

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	TTN7BL9	DHI1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	DTT	HSD11B1	10.967	5.178	5.865	6.377

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	DTT	HSD11B1	2.03E-01	-0.01	-0.08

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). Bioorg Med Chem Lett. 2008 Jun 15;18(12):3513-6.