Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3G74J)

Drug Name
Tamibarotene Drug Info
Synonyms Tamibarotene (oral, Alzheimer's disease)
Indication
Disease Entry ICD 11 Status REF
T-cell leukaemia 2A90 Phase 3 [1]
Alzheimer disease 8A20 Phase 2/3 [2]
Cross-matching ID
PubChem CID
108143
ChEBI ID
CHEBI:32181
CAS Number
CAS 94497-51-5
TTD Drug ID
DM3G74J

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Retinoic acid receptor alpha (RARA) TTW38KT RARA_HUMAN Modulator [3]
Retinoic acid receptor beta (RARB) TTISP28 RARB_HUMAN Modulator [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Retinoic acid receptor alpha (RARA) DTT RARA 3.096 4.45 3.892 5.6
Retinoic acid receptor beta (RARB) DTT RARB 4.498 5.661 6.267 4.591
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease T-cell leukaemia
ICD Disease Classification 2A90
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Retinoic acid receptor alpha (RARA) DTT RARA 4.46E-01 -0.04 -0.13
Retinoic acid receptor beta (RARB) DTT RARB 9.92E-02 -0.05 -0.21
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT04797780) SY-1425 Plus Azacitidine in Participants With Newly Diagnosed RARA-positive Higher-Risk Myelodysplastic Syndrome. U.S. National Institutes of Health.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2648).
3 Tamibarotene: a candidate retinoid drug for Alzheimer's disease. Biol Pharm Bull. 2012;35(8):1206-12.