Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3GU7K)

Drug Name
Pyridic ketone derivative 1 Drug Info
Synonyms PMID28594589-Compound-TABLE3c3
Cross-matching ID
PubChem CID
118041703
TTD Drug ID
DM3GU7K

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
ERK activator kinase 1 (MEK1) TTIDAPM MP2K1_HUMAN Inhibitor [1]
ERK activator kinase 2 (MEK2) TTTW2NY MP2K2_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
ERK activator kinase 2 (MEK2) DTT MAP2K2 4.372 6.068 6.352 6.894
ERK activator kinase 1 (MEK1) DTT MAP2K1 8.617 7.493 7.334 6.969
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
ERK activator kinase 2 (MEK2) DTT MAP2K2 2.46E-03 -0.71 -2.42
ERK activator kinase 1 (MEK1) DTT MAP2K1 6.84E-01 0.03 0.2
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 MEK inhibitors in oncology: a patent review (2015-Present).Expert Opin Ther Pat. 2017 Aug;27(8):887-906.