Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3JY2N)

Drug Name
NBI-37582 Drug Info
Synonyms UNII-PL877312XZ; PL877312XZ; RO-23-9424 dihydrochloride; SCHEMBL9844164
Indication
Disease Entry ICD 11 Status REF
Anxiety disorder 6B00-6B0Z Terminated [1]
Depression 6A70-6A7Z Terminated [1]
Cross-matching ID
PubChem CID
9690113
CAS Number
CAS 139263-69-7
TTD Drug ID
DM3JY2N

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Corticotropin-releasing factor receptor 1 (CRHR1) TT7EFHR CRFR1_HUMAN Antagonist [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Corticotropin-releasing factor receptor 1 (CRHR1) DTT CRHR1 5.3 3.755 5.206 3.926
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Anxiety disorder
ICD Disease Classification 6B00-6B0Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Corticotropin-releasing factor receptor 1 (CRHR1) DTT CRHR1 7.70E-01 -0.02 -0.1
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Strategies for producing faster acting antidepressants. Drug Discov Today. 2005 Apr 15;10(8):578-85.
2 CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008.