Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3KN2Q)

Drug Name

GI-270384X Drug Info

Synonyms

270384

Indication

Disease Entry	ICD 11	Status	REF
Inflammatory bowel disease	DD72	Terminated	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
E-selectin (SELE)	TTAU4D6	LYAM2_HUMAN	Modulator	[1]
Intercellular adhesion molecule ICAM-1 (ICAM1)	TTCT6F7	ICAM1_HUMAN	Modulator	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Intercellular adhesion molecule ICAM-1 (ICAM1)	DTT	ICAM1	7.993	5.81	6.662	5.926
E-selectin (SELE)	DTT	SELE	5.194	3.307	3.104	5.907

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Inflammatory bowel disease

ICD Disease Classification

DD72

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Intercellular adhesion molecule ICAM-1 (ICAM1)	DTT	ICAM1	5.21E-01	0.38	0.32

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Inhibition of endothelial cell adhesion molecule expression improves colonic hyperalgaesia. Neurogastroenterol Motil. 2009 Feb;21(2):189-96.