Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3MSZN)

Drug Name

5,N-Dihydroxythalidomide Drug Info

Synonyms

5,N-Dihydroxythalidomide; 5,1'-Dihydroxythalidomide; 5,1'-Dihydroxy thalidomide; 5,1'-Dihydroxy thalidomide, (+/-)-; CHEMBL479546; 1H-Isoindole-1,3(2H)-dione, 5-hydroxy-2-(1-hydroxy-2,6-dioxo-3-piperidinyl)-; 478785-12-5

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10356851
CAS Number: CAS 478785-12-5
TTD Drug ID: DM3MSZN

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Progesterone receptor (PGR)	TTUV8G9	PRGR_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Progesterone receptor (PGR)	DTT	PGR	1.848	1.888	1.263	0.138

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Progesterone receptor (PGR)	DTT	PGR	3.26E-38	-3.79	-2.5

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Progesterone receptor antagonists with a 3-phenylquinazoline-2,4-dione/2-phenylisoquinoline-1,3-dione skeleton. Bioorg Med Chem. 2008 Jul 15;16(14):7046-54.