Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3OUWC)

Drug Name

Domitroban Drug Info

Synonyms

S-145; UNII-742F5K270Q; 5,7-(3-Phenylsulfonylamino(221)bicyclohept-2-yl)heptenoic acid; Calcium 5,7-(3-phenylsulfonylaminobicyclo(221)hept-2-yl)-5-heptenoate hydrate; 742F5K270Q; 112966-96-8; S-1452; (+)-S-145; (+)-(Z)-7-((1R,2S,3S,4S)-3-Benzenesulfonamido-2-norbornyl)-5-heptenoic acid; 5-Heptenoic acid, 7-(3-((phenylsulfonyl)amino)bicyclo(221)hept-2-yl)-, (1R-(1alpha,2alpha(Z),3beta,4alpha))-; Domitroban [INN]; 5-Heptenoic acid, 7-((1R,2S,3S,4S)-3-((phenylsulfonyl)amino)bicyclo(221)hept-2-yl)-,; Amboxan; Anboxan; [3H]S-145

Indication

Disease Entry	ICD 11	Status	REF
Thrombosis	DB61-GB90	Discontinued in Preregistration	[1]

Cross-matching ID

PubChem CID: 5312138
ChEBI ID: CHEBI:135586
CAS Number: CAS 112966-96-8
TTD Drug ID: DM3OUWC

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thromboxane A2 receptor (TBXA2R)	TT2O84V	TA2R_HUMAN	Antagonist	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Thromboxane A2 receptor (TBXA2R)	DTT	TBXA2R	6.075	5.925	6.729	6.096

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Thrombosis

ICD Disease Classification

DB61-GB90

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Thromboxane A2 receptor (TBXA2R)	DTT	TBXA2R	2.78E-04	-0.11	-0.31

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1979).
2	The effect of a novel thromboxane A2 (TXA2) receptor antagonist (S-1452) on the antigen-induced bronchoconstriction and airway hyperresponsiveness in guinea pigs. Prostaglandins Leukot Essent Fatty Acids. 1993 May;48(5):343-9.