Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3T612)

• Drug Name: 7-Hydroxy-4-phenylcoumarin Drug Info
• Synonyms: 7-Hydroxy-4-phenylcoumarin; 2555-30-8; 7-hydroxy-4-phenyl-2H-chromen-2-one; 7-hydroxy-4-phenylchromen-2-one; NSC78474; 4-Phenyl-7-hydroxycoumarin; UNII-L0487H6Q0H; CHEMBL325841; L0487H6Q0H; 7-Hydroxy-4-phenyl-chromen-2-one; 7-oxidanyl-4-phenyl-chromen-2-one; NSC-78474; 2H-1-Benzopyran-2-one,7-hydroxy-4-phenyl-; 2H-1-Benzopyran-2-one, 7-hydroxy-4-phenyl-; 4-Phenylumbelliferone; PubChem8691; Coumarin derivative, 3c; AC1NSAV1; 7-Hydroxy4-phenylcoumarin; Oprea1_774373; 7-hydroxy-4-phenyl coumarin; MLS001143868; SCHEMBL2987658

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5357479
  CAS Number: CAS 2555-30-8
  TTD Drug ID: DM3T612

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aldose reductase (AKR1B1)	TTFBNVI	ALDR_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Aldose reductase (AKR1B1)	DTT	AKR1B1	7.436	8.652	9.874	8.066

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Aldose reductase (AKR1B1)	DTT	AKR1B1	1.08E-20	0.94	1.58

References

• [1] 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5630-3.