Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3WDOY)

Drug Name

[(2-aminooxyethyl)methylamino]-5'-deoxyadenosine Drug Info

Synonyms

MAO; 5'-DEOXY-5'-[N-METHYL-N-(2-AMINOOXYETHYL) AMINO]ADENOSINE; 112621-39-3; AC1L9JAL; MAOEA, 5; SCHEMBL956861; Adenosine,5'-[[2-(aminooxy)ethyl]methylamino]-5'-deoxy- (9CI); CHEMBL461780; CTK4A7898; BDBM28431; AKOS030589585; 5'-[(2-Aminooxyethyl)methylamino]-5'-deoxyadenosine; 5'-{[2-(aminooxy)ethyl](methyl)amino}-5'-deoxyadenosine; (2R,3S,4R,5R)-2-[[2-aminooxyethyl(methyl)amino]methyl]-5-(6-aminopurin-9-yl)oxolane-3,4-diol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 446204
TTD Drug ID: DM3WDOY

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
S-adenosylmethionine decarboxylase proenzyme (AMD1)	TTBFROQ	DCAM_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
S-adenosylmethionine decarboxylase proenzyme (AMD1)	DTT	AMD1	6.747	6.763	7.033	6.593

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
S-adenosylmethionine decarboxylase proenzyme (AMD1)	DTT	AMD1	4.41E-05	0.37	0.61

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues ... J Med Chem. 2009 Mar 12;52(5):1388-407.