Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3ZW6A)

Drug Name

VAN-10-4-eluting stent Drug Info

Synonyms

INC-105-eluting stent, Inncardio/University of Strathclyde; VAN-10-4-eluting stent, University of Strathclyde; Marigold compound (drug-eluting stent, restenosis), Inncardio/University of Strathclyde

Indication

Disease Entry	ICD 11	Status	REF
Artery stenosis	BD52	Phase 1	[1]

Cross-matching ID

TTD Drug ID: DM3ZW6A

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Extracellular signal-regulated kinase 1 (ERK1)	TT1MG9E	MK03_HUMAN	Inhibitor	[2]
Extracellular signal-regulated kinase 2 (ERK2)	TT4TQBX	MK01_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Extracellular signal-regulated kinase 2 (ERK2)	DTT	MAPK1	5.848	6.896	7.236	6.465

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Artery stenosis

ICD Disease Classification

BD52

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Extracellular signal-regulated kinase 2 (ERK2)	DTT	MAPK1	6.78E-05	1.12	2.73

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Drug-Eluting Stent for High Risk Patients. University of Strathclyde Glasgow. 2015
2	WO patent application no. 2013,1850,32, Nanotherapeutics for drug targeting.