Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM43GPX)

Drug Name
BVI-007 Drug Info
Indication
Disease Entry ICD 11 Status REF
Myocardial infarction BA41-BA43 Phase 1 [1]
Thrombotic stroke 8B20 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DM43GPX

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Thrombopoietin (THPO) TTCG5PE TPO_HUMAN Inhibitor [2]
Thrombopoietin receptor (MPL) TTIHYA4 TPOR_HUMAN Antagonist [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Thrombopoietin receptor (MPL) DTT MPL 2.7 3.186 2.35 3.766
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Myocardial infarction
ICD Disease Classification BA41-BA43
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Thrombopoietin receptor (MPL) DTT MPL 8.96E-01 0.07 0.28
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027040)
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1722).