Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM459Q7)

Drug Name

BMS-833923 Drug Info

Synonyms

BMS-833923; 1059734-66-5; BMS 833923; XL139; XL 139; BMS833923; UNII-41J7ZJ239R; N-(2-Methyl-5-((methylamino)methyl)phenyl)-4-((4-phenylquinazolin-2-yl)amino)benzamide; 41J7ZJ239R; XL-139; C30H27N5O; N-(2-methyl-5-((methylamino)methyl)phenyl)-4-(4-phenylquinazolin-2-ylamino)benzamide; Benzamide, N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]-; BMS-833923 free base anhydrous; XL139 mesylate; SCHEMBL4138073; GTPL8202; CHEMBL3545403; EX-A789; MolPort-035-395-837; HMS3653O09; BCP07837; AOB87352

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1b	[1]

Cross-matching ID

PubChem CID: 57662985
CAS Number: CAS 1059734-66-5
TTD Drug ID: DM459Q7

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Smoothened homolog (SMO)	TT8J1S3	SMO_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Solid tumour/cancer

ICD Disease Classification

2A00-2F9Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Smoothened homolog (SMO)	DTT	SMO	4.01E-06	-0.18	-0.35

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8202).
2	Clinical pipeline report, company report or official report of Exelixis (2011).